With hawkish lawmakers eager to pass new sanctions through Congress to prod the Islamic republic into a lasting deal that prevents Iran from developing a nuclear weapon, experts warned that attempts to impose economic penalties could rip apart the delicate negotiation process.
Iran and world powers agreed to extend terms of an interim deal - which include limited sanctions relief - for another seven months as they work toward a final accord, and President Barack Obama has largely been given a free hand by Congress to deal with Tehran over the past year.
Such a move could "undermine our entire position," George Perkovich, vice president for studies at the Carnegie Endowment for International Peace, told AFP about US negotiating efforts.
"I can guarantee you if Congress passes new unilateral sanctions, the Iranians aren't going to become more accommodating. It'll be quite the opposite."
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Not only will Tehran show fury, it could erode international support for the economic embargo and "alienate Turkey, India, China and other countries that you need to uphold sanctions."
But Republicans, and some prominent Democrats, are keen to press ahead.
"We believe this latest extension of talks should be coupled with increased sanctions and a requirement that any final deal between Iran and the United States be sent to Congress for approval," Senate Republicans John McCain, Lindsey Graham and Kelly Ayotte said Monday in a statement.