Professor Richard Semba, of the Johns Hopkins University School of Medicine, Baltimore, and colleagues found that the antioxidant resveratrol found in red wine, chocolate and grapes was not associated with longevity or the incidence of cardiovascular disease, cancer and inflammation.
For the study, researchers studied 783 elderly people in two small towns in Tuscany.
The volunteers gave details about their daily diets as well as urine samples for measurement of their resveratrol intake.
But urinary resveratrol was not linked with death risk, heart disease risk or cancer risk, researchers found.
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It was not associated with any markers of inflammation in the blood.
"In conclusion, this prospective study of nearly 800 older community-dwelling adults shows no association between urinary resveratrol metabolites and longevity," the authors wrote in the journal JAMA Internal Medicine.
"This study suggests that dietary resveratrol from Western diets in community-dwelling older adults does not have a substantial influence on inflammation, cardiovascular disease, cancer, or longevity," they wrote.
Semba said that any benefits of drinking wine or eating dark chocolate or berries, if they are there, must come from other shared ingredients.
"These are complex foods, and all we really know from our study is that the benefits are probably not due to resveratrol," he said.