Despite victories in both the T20 and One-Day International series earlier in the tour, the tourists have shaped up as a far more vulnerable outfit in the traditional format of the game.
The home side, who remain mired in the lower reaches of the international rankings, look set to make further alterations to their line-up in the quest for a consistent winning formula.
Pakistan topped the Test rankings last September following their drawn series in England.
After much speculation Misbah has announced that this series will be his last before retiring from the international game.
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And only last week fellow veteran Younis Khan, Pakistan's most prolific run-scorer in Test history, also revealed that the West Indies tour will be his last in national colours.
Khan goes into the match needing just 23 more runs to become the first Pakistani to amass 10,000 runs in Tests, and while the milestone will be of immense personal significance, of even greater concern to the visiting team is completing their first-ever Test series triumph in the West Indies by the time the final Test concludes in Dominica in mid-May.
Three of the representative team who starred with the bat against the tourists - Kieran Powell and the uncapped pair of Vishaul Singh and Shimron Hetmyer - were named in the West Indies squad of 13 for the opening Test although it is anticipated that Hetmyer, captain of the victorious team at last year's Under-19 World Cup in Bangladesh, and fast-medium bowler Miguel Cummins will be omitted from the final eleven.
Notwithstanding his outstanding entry to senior international cricket during the limited-over leg of the tour, Pakistan's Shadab Khan may not make his Test debut alongside established wrist-spinner Yasir Shah unless the pitch looks extremely dry before the toss on Friday morning.
Teams (probables):
West Indies: Jason Holder (capt), Kraigg Brathwaite, Kieran Powell, Shai Hope, Vishaul Singh, Jermaine Blackwood, Shane Dowrich, Roston Chase, Devendra Bishoo, Alzarri Joseph, Shannon Gabriel.
Pakistan: Misbah ul Haq (capt), Azhar Ali, Ahmed Shehzad, Babar Azam, Younis Khan, Asad Shafiq, Sarfraz Ahmed, Mohammad Aamir, Wahab Riaz, Yasir Shah, Mohammad Abbas.