The Supreme Court dismissed the review petitions filed by Sharif, his children and Finance Minister Ishaq Dar against the apex court's Panama Papers judgement of July 28.
The top court had disqualified Sharif and ordered the filing of corruption references against Sharif, his children - Hussain, Hassan and Maryam Nawaz - son-in-law retired Captain Mohammad Safdar, and incumbent Finance Minister Ishaq Dar.
With the rejection of the petitions, Sharif has exhausted all legal options to challenge his disqualification, jeopardising his chances to stage a political comeback.
While addressing a women convention, she reiterated her earlier claims that Sharif was disqualified because he did not take income from his son.
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"Do you accept this unjust verdict?" she asked her supporters, adding "If you are against the verdict then vote for lion on September 17."
"Support Nawaz, support progress," she said to PML-N workers, Geo TV reported.
Maryam is handling the Lahore election campaign while her mother and PML-N candidate for the by-poll, Kulsoom Nawaz, undergoes treatment for throat cancer in London.
A total of 44 candidates will contest the by-poll in Lahore, a stronghold of the Sharifs.