The Virgin Group founder has recorded a cameo for the series and will play a neighbour to Mr Burns, reported Entertainment Weekly.
"Richard Branson is the Flanders to Mr Burns. He's Mr Burns's nosy neighbour," executive producer Al Jean said.
Branson previously made an appearance as himself in season 22's 'Loan-a Lisa', which also starred Facebook's Mark Zuckerberg.
'Parks and Recreation' stars Nick Offerman, Sarah Silverman, 'Frasier' star David Hyde Pierce, Willem Dafoe and Jane Fonda will also lend their voice talents to the show this season.
'The Simpsons' will return on September 28 on Fox.