"Shut up, you disgusting, pill-popping sexual deviant scum," he began addressing the glittering, grinning crowd while taking a sip from a glass of fizzing beer in his opening remarks.
"I'm going to do this monologue and then go into hiding," the host said before adding, "I'm going to get this monologue out of the way and then go into hiding. Not even Sean Penn will find me... Snitch."
He went on to let everyone know he has no time, or interest in the Golden Globes themselves. "If you do win tonight, remember that no one cares about that award as much as you do," he said.
"Don't get emotional; it's embarrassing, OK? That award is, no offense, worthless."
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He casually laid into a wide swath of people and addressed current events at the same time.
Gervais touched up on a raging topic in Hollywood-- pay disparity -- and said he believed in equal pay for women in the industry but before anyone expected something serious, he remarked, "I'm getting paid exactly the same as (co-hosts) Tina (Fey) and Amy (Poehler) did last year... It's not my fault if they want to share the money."
"She became a role model for trans people everywhere...," he said before adding a tongue-in-cheek comment, "She didn't do a lot for women drivers, but you can't have everything," referring to Jenner's run-in with the law after a traffic accident.
Gervais returned to host the Golden Globes for the fourth time.
Noting that NBC had no nominations of its own, which made it a "fair and impartial" network to host the show, Gervais said, "Nothing in it for them tonight; they don't care," he noted.
One of the awkward moments of the evening was between Gervais and actor-filmmaker Mel Gibson.
While introducing the filmmaker, Gervais said, "Listen, I'm sure it's embarrassing for both of us and I blame NBC for this terrible situation. Mel blames - we know who Mel blames. I still a feel bit bad for him. Mel has forgotten all about it, apparently, that's what drinking does," the host began.
"I want to say something nice about Mel before he comes out... I'd rather have a drink with him in his hotel room tonight than Bill Cosby," Gervais quipped.
"I love seeing Ricky once every three years because it reminds me to get a colonoscopy," Gibson said.
When Gervais returned on stage, he whispered in Gibson's ear, "Can I ask you a question? I think we all want to ask you this."
Gervais' question made a direct reference to Gibson's derogatory comments towards a female police officer, which hit headlines in 2006. The question was censored for TV viewers.
In 2012, Gervais introduced Gibson while poking fun at his 2006 outburst at a police officer and widely-publicised anti-semitic remarks.
Gervais' another target was TV star Charlie Sheen, who revealed last year he was HIV positive.