The warning came almost two weeks after Islamabad deported a Turkish teacher Kacmaz Mesut, his wife and two young daughters, in defiance of a court ruling.
The family was picked up in September by plain-clothed officers, blindfolded and bound before being loaded into trucks and taken away.
Some 285 Turkish nationals in Pakistan are also at risk and Islamabad must protect them "from forcible repatriation, arbitrary arrest," according to a statement by the International Federation for Human Rights.
The father of the family was a former director of PakTurk International Schools and Colleges, private schools popular in Pakistan allegedly backed by US-based Turkish preacher Fethullah Gulen's Hizmet group.
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Ankara accuses Gulen of masterminding a coup attempt against Erdogan's government in 2016 -- an allegation the cleric strongly denies -- and is seeking his extradition from the US.
The other 285 Turkish nationals are teachers associated with the PakTurk schools and their families, and they have been facing deportation to Turkey since November 2016.
The rights activists said that Turkey has already succeeded in obtaining the forcible repatriation of teachers linked to the PakTurk schools from Malaysia, Myanmar, and Saudi Arabia.
"Pakistan flouted its international obligations simply to appease the Turkish government. It must reverse this approach with respect to the 285 Turkish nationals," Mehdi Hasan, chair of the Human rights Commission of Pakistan (HRCP) said.
Last November Pakistan deported dozens of Turkish teachers tied to PakTurk schools after a visit from Turkey's President Tayyip Erdogan, sparking small demonstrations in major cities.