Roach has been ruled out of the second and final Test along with the one-dayers due to a shoulder injury, while Pollard has been rested from the ODIs due to an undisclosed niggle.
West Indies team physiotherapist CJ Clark said Roach's injury is uncommon among cricketers.
"Kemar has not made the expected recovery from the shoulder injury that kept him out of the first Test and he is returning to the Caribbean for ongoing management and subsequent physical rehabilitation," said Clark.
The 25-year-old Roach has been the bright spark in the West Indies attack over the last three years in particular.
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He has taken 85 wickets at 27.71 runs apiece in 23 Tests and has risen in the ICC Test bowling rankings to become the only West Indian in the Top-20 at 14th.
"We're sad to announce that Kemar has to return home to the Caribbean and will not have an opportunity on this tour, where we felt he could have made a major difference," said West Indies head coach Ottis Gibson.
West Indies ODI Squad: Dwayne Bravo (capt), Tino Best, Darren Bravo, Johnson Charles, Narsingh Deonarine, Chris Gayle, Jason Holder, Sunil Narine, Veerasammy Permaul, Kieran Powell, Denesh Ramdin, Ravi Rampaul, Darren Sammy, Marlon Samuels, Lendl Simmons.