The "King of the Nerds" host, 60, was behind the wheel when the crash happened. He crossed the dividing line and drove his Mercury sedan into oncoming traffic before colliding head-on with a Honda semi-truck, reported Ace Showbiz.
His car was totalled as seen in the picture posted on Twitter by The Durango Herald.
It might have been a fatal collision if the actor and his wife did not wear seat belts, police said.
"The fact that they were wearing seat belts is why they are with us today," Sgt. James Saunders explained.
He and his wife were rushed to hospital with serious but non-life threatening injuries. They were taken to Southwest Memorial Hospital and then transferred to Mercy Regional Medical Center in Durango. The driver of the other vehicle was uninjured.