The "Spy Kids filmmaker is teaming up with Warner Bros and Terry Rossio ("The Lone Ranger") to adapt a pre-existing screenplay penned by Dan Mazeau ("Wrath of the Titans").
It is not clear yet what this new storyline for kid adventurer Jonny Quest's big screen adventure will be, according to The Hollywood Reporter.
A prior film adaptation starring Zac Efron as "Quest" and Dwayne Johnson as bodyguard Race Bannon was announced in 2009, only for development to stall.
Hanna-Barbera originally aired the animated series for a single season in 1964, but syndication kept the series popular in the ensuing decades.
"Jonny Quest" was later revived in New Adventures and Real Adventures spin-offs in the 1980s and 1990s. Computer games, a comic book series and home video films followed.