"Extraordinary work by all of our team, the Ryder Cup is OURS!," Rome's bid co-ordinator Marco Durante said in a post on Twitter immediately after the announcement.
The cream of world golf will descend on the Marco Simone Golf and Country Club in seven years' time for the biennial contest between Europe and the United States, Ryder Cup organisers announced in a statement.
"The Italian capital city of Rome will host The Ryder Cup for the first time in 2022," it said, adding that the "golf's greatest team event will be staged on the Continent of Europe for the third time."
But after inspecting all four sites in recent months, organisers finally plumped for Rome, whose venue is only 17km from the centre of the 'Eternal City'.
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From the 17th tee, players and fans alike can spot the dome of Saint Peter's Basilica on a clear day, although the venue's various transport links to the capital and its thousands of hotels were a key factor in the final decision, as well as Italy's pledge to use their staging of the tournament to further develop the sport throughout the country.
Founded by and still owned by celebrated fashion designer Laura Biagiotti and her family, the Marco Simone Club hosted the Italian Open in 1994.
Rome organisers now have seven years in which to carry out the changes to the course that will be necessary to test the mettle of the world's top golfers
The statement added: "The Italian bid was consistently strong across all the areas evaluated and in particular in their pledge to undertake a complete reconstruction of the golf course at Marco Simone to the highest standards demanded by Ryder Cup Europe, in addition to a hugely significant commitment to the Italian Open in terms of guaranteeing a EUR7 million prize fund for the championship for 11 years, beginning in 2017."