The first movie focused on a group of young men escaping through a deadly maze and only had one female lead, played by Kaya Scodelario.
Salazar will play Brenda, a character who runs around with another group of teens (as that group's lone female), who ends up paired with Dylan O'Brien's character when both end up on the run in tunnels underneath a city, said The Hollywood Reporter.
Director Wes Ball is back for the sequel as are the producers, Temple Hill Entertainment and the Gotham Group. The film will be released next year.