The "Charmed" actress, 42, slammed the former Olympian for stating at Glamour's ceremony that the "hardest part about being a woman is figuring out what to wear", reported Us magazine.
"Caitlyn Jenner you do not understand what being a woman is about at all. You want to be a woman and stand with us- well learn us. We are more than deciding what to wear.
"We are more than the stereotypes foisted upon us by people like you. You're a woman now? Well learn that we have had a VERY different experience than your life of male privilege," McGowan wrote in a Facebook post.