The poem is titled "8 Million to One," which has a reference to the population of New York City, reported Entertainment Weekly.
Ivanka is the daughter of O'Donnell's nemesis and Presidential candidate Donald Trump.
In the poem the 54-year-old comedian writes about the distressed state of her mind in the wake of the first presidential debate, during which Trump renewed his longtime public feud with her.
"Depression clings to me," she writes.
O'Donnell by chance met Trump's elder daughter at a restaurant and introduced herself. According to the poem the two did connect on some level.