The armed men came in a car and stopped the van, which was carrying cash to Ferozepur following which they looted the cash box at gun-point, police said.
After loading the cash box in their car, they locked the bank employees inside the van and sped towards Ludhiana, they said.
The accused brandished an AK-47 rifle along with other firearms, police said.
A case has been registered against the unidentified persons, Senior Superintendent of Police Ludhiana (rural), Ravcharn Singh Brar said.