The 49-year-old actor, who plays Lord M, will not be seen in the show from now on, the channel ITV confirmed to the RadioTimes.
It was during the third episode of the second installment of the series that Lord M's health seemed to deteriorate.
The followers of the show had raised their doubts on social media about the status of the character played by Sewell, after the Queen went to visit the former British prime minister with a gift.
This is the second death in "Victoria", after the Queen's beloved puppy, Dash suddenly passed away.
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