Agriculture Minister Nokolai Fyodorov's stark comments represented Moscow's first admission that its decision to strike back at US and EU sanctions with sweeping food bans may have long-term costs for both its budget and consumers.
The trade war is part of a broader crisis in East-West relations sparked by Russia's perceived attempts to split strife-torn Ukraine in two after Kiev's decision to seek a closer political and economic alliance with Europe.
It also imports huge volumes of Australian and European meat along with US poultry and Norwegian salmon - all banned under Russian President Vladimir Putin's orders earlier this month.
The agriculture minister told the Rossiya 24 rolling news channel that "the volume of additional support needed to substitute for the embargoed items in full - if we are talking about short-term, through the end of the year - is tens of billions of rubles".
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"But there are also medium-term measures: next year and in the subsequent years, you could say that this sum will be measured in the hundreds of billions of rubles," Fyodorov said.
His estimates suggest that Russia may have to spend at least USD 10 billion on farm subsidies over the coming few years.
That level of support has not been provided for in the federal budget and may require other popular social programmes to be cut.
Russia's economic slowdown has limited the government's tax revenues while jitters over Ukraine's future and possible additional Western sanctions have kept investors from filling the void left by cautious levels of state spending.
"In order to enjoy greater production, you need money spent on agricultural modernisation, especially in the dairy farming industry," Shagaida said in a telephone interview.
"You need cheep loans and enormous state support," the economist said.
"You may then see some results in vegetable farming, for example, as early as next year. Even with dairy, you might see progress within two years. But the rest will take at least five years," Shagaida said.