The ministry's statement today follows media reports claiming that Russia could be preparing to set up another base in Qamishli in northeastern Syria near the border with Turkey.
The ministry's spokesman, Maj-Gen Igor Konashenkov, said that the military has no intention to set up any additional air bases or advance airfields in Syria.
Russian warplanes have flown nearly 6,000 combat missions since Moscow launched its air campaign in Syria on September 30.
The Russian warplanes are based at Hemeimeem air base in Syria's coastal province of Latakia.