The 39-year-old "Deadpool" star said he would immediately say yes if the offer ever comes, reported Digital Spy.
"I'm not one of those guys that's real precious and sensitive about that. I would totally do that in a heartbeat...It'd be so much fun. That job was so much fun for me," Reynolds said.
The ABC sitcom was originally broadcast from March 10, 1998, to May 16, 2001. It starred Reynolds, Traylor Howard and Richard Ruccol in lead roles.