In what has become the largest outbreak of the virus outside Saudi Arabia, a 72-year-old woman died Friday after being infected by a MERS patient at a hospital, the health ministry said.
Two more fatalities were reported later -- both men in their 70s who had come in contact with a MERS patient -- bringing the country's total to 13 dead, Yonhap news agency said.
The number of new cases, however, fell to four, down from 14 on Thursday, bringing to 126 the total number of people in South Korea diagnosed with the virus.
"The number of newly confirmed cases has fallen sharply and there are little risks of the virus spreading through airborne transmissions or to communities outside hospital settings", the ministry said in a statement.
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"Therefore, we ask the people to conquer their fear and engage in day-to-day business," it said.
Yesterday, the outbreak forced the central Bank of Korea to cut its key interest rate by 0.25 percentage points as the spread of the virus dampened already weak consumer sentiment.
More than 54,000 foreign travellers have cancelled planned trips to South Korea so far this month, according to the Korea Tourism Board.
Following criticism that the government bungled the initial response, a Seoul hospital was closed temporarily over fears the facility might be another source of mass infection, the first such closure in the capital.
Mediheal Hospital will remain shut until June 23, a Seoul City spokesman told AFP.
A total of 52 healthcare facilities including 18 in Seoul and 16 in the surrounding Gyeonggi Province have been exposed to the virus.
But Samsung Medical Centre, where 58 out of the 126 confirmed infected people contracted the disease -- the biggest single group -- remains open after being sanitised.