Mumbai have three matches out of five in the tie and are currently leading the duel 2-0 on points.
The world number 10, who is coming into the match at the back of a defeat against world number 1 Tai Tzu Ying, proved to be no match against Beiwen in the opening game.
The US Shuttler was using the length of the court perfectly, tormenting the Indian with her superb cross-court drops and smashes and raced to victory in the opening game in no time.
In the final game, Saina was in no mood to let go of the opportunity to pounce on her opponent and brought all her experience into play. She made full use of the tiring US player and went into the break with a lead of 8-4.
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The tie is extremely crucial from Mumbai's point of view as they are currently languishing at the bottom of the table with six points.
A loss here means they will be virtually out of semifinals reckoning, but a win with good margin will keep them alive in the race.
Earlier in the day, Sameer Verma picked up a comfortable 15-6, 15-14 straight games victory against his compatriot Harshit Aggarwal to give Mumbai Rockets a huge 2 (-1) over Awadhe Warriors in this five-match duel.
He did try to make a comeback in the second game and even though he was looking in better touch and took the game to the wire, it was Sameer who sealed the deal with a smash.
In the first match of the day, the mixed doubles pair of Lee Yong Dae and Gabriela Stoeva pulled off a major coup by beating Christinna Pedersen and Tang Chun Man 15-10, 14-15, 15-7 to give Mumbai the early lead into the tie.
In the opening game of the match, the Mumbai duo were quick off the blocks and gave their team an early 8-2 lead. They dominated the proceeding from the word go and even though the Awadhe pair tried to show some resistance, they sealed the game in no time.
Christinna and Tang made a terrific comeback and even though they were challenged to the hilt, they enjoyed a slim lead throughout the second game. The Mumbai pair stayed hot on Awadhe's tail and when down 12-14, they saved two game points to tie the score 14-14.
With the match tied 1-1, Mumbai were in relentless mood and completely dominated the Awadhe pair to close the match with a huge margin.