World number six Saina has given her entry for the championships to be held at Siri Fort Sports Complex here from December 16-23.
Saina last played in the 2007 National championships in Patna.
The 69th Inter-Zonal championships will be held alongside 78th edition of the national competition. Delhi will be hosting the nationals after a gap of 14 years.
In men's singles, defending champion P Kashyap will face a strong challenge from the likes of Thailand GP Gold winner K Srikant, Ajay Jayaram, H S Prannoy.
More From This Section
"Almost every top player in the country have confirmed their entries for the nationals and we are confident that the tournament will be a grand success," said Apinder Sabharwal, Organising Secretary.
The championships will witness 333 players vying for the five coveted titles and a total prize purse of Rs 10 lakh.
ATS infrastructure Ltd, a residential real estate company, will be sponsoring the event.