Former World No.1 Saina upstaged Olympic silver-medallist P V Sindhu in the national finals last week to claim her third championship crown, while Prannoy stunned Kidambi Srikanth to clinch his maiden title at the 82nd edition of the event at Nagpur.
Interestingly, both Saina and Prannoy are ranked 11th in the Destination Dubai Ranking and are racing against time to book a berth at next month's Super Series Final with just two Super Series events -- China Open and Hong Kong Open -- left in the calender.
However, Srikanth, who clinched four titles and reached five finals in this season, will be taking a break this week to nurse a muscle strain.
Sindhu has also been in impressive form this season as she clinched two super series titles -- India Open and Korea Open -- besides winning a silver at the World Championship. She too will be pumped up to get back to her winning ways after the setback against Saina.
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If the Indian can cross the first two rounds, she might face off against Japan's Nozomi Okuhara, who had beaten her to a coveted gold at the Glasgow world championship in August after a marathon final.
Among others in men's singles, B Sai Praneeth, who has been a bit off-colour ever since his Singapore Open triumph, will take on Denmark's Anders Antonsen. Ajay Jayaram, who had skipped the Denmark and French Open, will square off against Japan's Kazumasa Sakai.
The Verma brothers -- Sourabh and Sameer -- will also be back in action after skipping the last two super series events due to fitness issues.
In doubles, the mixed pair of Pranaav Jerry Chopra and N Sikki Reddy, who had reached the semifinals at Japan Open, will have to fight it out with the fifth-seeded Chinese combo of Zheng Siwei and Huang Yaqiong.
The men's pair of Manu Attri and B Sumeeth Reddy, who won the Nationals last week, faces the top-seeded Indonesian combo of Marcus Fernaldi Gideon and Kevin Sanjaya Sukamuljo.
Satwiksairaj Rankireddy and Chirag Shetty will take on fifth-seeded Chinese combo of Liu Cheng and Zhang Nan.
In the qualifiers tomorrow, national champions Satwiksairaj and Ashwini will look to make it to the main draw when they face Chinese Taipei's Lee Jhe-Huei and Wu Ti Jung.
In men's singles, Commonwealth Games champion Parupalli Kashyap will begin his campaign in the qualifiers, taking on China's Guo Kai.