After a lacklustre season last year, in which she was plagued by injuries and failed to win a single title and her world ranking also took a beating, Saina now starts as a top seed in a field that has 16 other Indians.
Among foreign shuttlers, world number 18 Lindaweni Fanetri of Indonesia and world number 39 Xuan Deng of China will be the top challengers.
In the last edition, the 23-year-old had conceded her first round match, citing injury and fatigue. The girl from Hyderabad has not played in the Senior Nationals since 2007 and last month, she had to skip the Nationals once again as she was down with cold and cough.
The London Olympics bronze medallist, who is currently ranked No.8 in the world, will open her campaign against Matilda Petersen of Sweden on Wednesday. Even though she has not been in the best of form, the road ahead should be an easy one for Saina.
Last edition's runners-up, Sindhu will start her campaign against Malaysian Li Lian Yang, who is ranked 108 in the world. Given the form, the world championship bronze medallist is right now, Sindhu is likely to reach the finals without much ado.