After a semifinal finish at the India Open last week, Saina made a positive start to her campaign at the USD 550,000 event here as she notched up her sixth win over Thailand's Nitchaon Jindapol 21-16 21-7 in 30 minutes.
The 26-year-old Indian, seeded third, will next meet Korea's Bae Yeon Ju, who had ended Sindhu's campaign last week in New Delhi.
The two-time bronze medallist at World Championship, Sindhu will next take on Korean Sung Ji Hyun, seeded seventh, who had lost to Saina in India Open last week.
However in men's singles, Rio Olympics hopefuls H S Prannoy and K Srikanth failed to cross the opening hurdle.
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Srikanth, who failed to defend his title at India Open last week after going down to China's Tian Houwei in the opening round, continued to find the going tough in super series events.
(REOPENS SPF 10)
Later in the day, Ajay Jayaram, who is also running for an Olympic qualification, suffered a 17-21 14-21 loss to Hu Yun of Hong Kong.
In men's doubles, Indian combo of Manu Attri and B Sumeeth Reddy lost 11-21 10-21 to Russian pair of Vladimir Ivanov and Ivan Sozonov.