Olympic bronze medallist Saina, who broke her India Open jinx last year after a series of early exits in the previous editions, will enter the tournament after a quarterfinal and semifinal finish at the All England and Swiss Open, respectively.
Plagued by an ankle injury that she suffered last year, Saina was forced to skip a few tournaments early in this year and she will be eager to reach her peak ahead of the Rio Olympics in August.
Srikanth, on the other hand, blown hot and cold so far in the season. The Indian won the Syed Modi Grand Prix Gold in January but lost in the second round of All England and third round at German Open last month.
"I know I have lost a few matches but I am satisfied with my game. I am confident of defending my title. I have been playing well. I won the Syed Modi and also reached the semifinals at Malaysia Masters," Srikanth told PTI.
Also Read
The field will be led by two-time Olympic champion Lin Dan and former world no. 1 Lee Chong Wei.
Among other Indians, P V Sindhu will start her campaign in the main draw against Jeanine Cicognini on Wednesday after Carolina Marin pulled out.
(REOPENS DEL 63)
In red-hot form after his Swiss Open win last week, H S Prannoy, who is running for the Olympic qualification, will also be one of the contenders who will be a tough nut to crack as he starts his campaign against Thailand's Tanongsak Saensomboonsuk in the men's singles event of the USD 300,000 tournament.
With P Kashyap pulling out as he is still recovering from a knee injury, B Sai Praneeth will be entering the main draw. The Indian had beaten Lee Chong Wei in the opening round of the All England championship.
"I won't be participating at the India Open owing to the injury sustained at the German Open. Continuing to train harder," he said.
In women's doubles, Jwala Gutta and Ashwini Ponnappa will square off against Korea's Go Ah Ra and Yoo Hae Won, while Manu Attri and B Sumeeth Reddy will face sixth seeds China's Liu Xiaolong and Qiu Zihan.