After failing to defend her title at Denmark Open last week, Saina will now open her campaign at the French Open against Thailand's Nichaon Jindapon on Wednesday.
The Indian had been in good form at the Indian Badminton League and though she looked to be in good touch for most part of the tournament, Saina could not prevent a quarterfinal exit in the Denmark Open, her first event since the IBL.
"Now I am looking forward to the French Open, where I had finished as runners up. I don't know what God has in store for me. I will give my best and hope to do well," added the Indian, who is ranked fourth in the world.
But at the Stade Pierre De Coubertin, it will a bigger challenge when Sindhu faces sixth seed Korean Ji Hyun Sung, who had ended Saina's run at Denmark.
In the men's singles, Parupalli Kashyap will clash with top seed and world number one, Lee Chong Wei, while world number 25 Ajay Jayaram will meet Kazumasa Sakai of Japan in the opening round.