"If laughter is the best medicine... Then this is your local chemist... Will strive to put a smile on your face...," Sajid debuted with the tweet.
The actor-director was welcomed by filmmaker sister Farah Khan and friend Karan Johar.
"So my brother is finally on it! For the funniest tweets follow him on @SimplySajidK...," tweeted Farah.
Karan wrote, "And the man with an incredible sense of humor is on twitter! Director and now columnist! Sajid khan! @simplysajidk."
Living up to his promise of making everyone laugh, the 43-year-old funnyman's second tweet read, "'Never be a quitter' my teacher used to say...