Fourth seed Myneni overcame the challenge of his singles rival 6-1 2-6 6-3 in one hour and 35 minutes in the quarterfinals of the USD 50,000 hard court tournament.
Up next for the Indian is fifth Italian Thomas Fabbiano, who knocked out top seed and world number 85 Marcel Granollers from Spain 6-3 6-4.
It will be third semifinal on the Challenger tour for Myneni this season. He had reached the last-four stage at Samarkand and Batman (Turkey) events.
Saketh is only Indian surviving in the singles event following defeats of Sanam Singh, Somdev Devvarman, Sumit Nagal and Jeevan Nedunchezhiyan.
Later in the day, Sanam and Saketh, seeded third, rallied to beat Italian qualifiers Alessandro Bega and Fabbiano 5-7 6-4 10-5 in the quarterfinals.