The first from "Explorers on the Moon", widely regarded as one of the two best Tintin adventures, could fetch up to USD 1 million.
The page, entitled "We walk on the moon", has the boy reporter, his dog Snowy and blundering sidekick Captain Haddock making their first moon walk from their red and white rocket.
With the 1954 book viewed as one of the artist Herge's masterpieces, the Paris auction house Artcurial values it at least 900,000 euros (USD 950,000).
The late Belgian artist already holds the world record for the sale of a comic strip.
More From This Section
Today's sales are expected to break records for single strips.
Rival auction house Christie's is putting drawings from another rare Herge strip up for sale later in the day in Paris.
It said the page from the unfinished story "Tintin and the Thermozero" -- estimated at 250,000 euros -- was the first ever to come to market.
Why the artist never finished the tale of espionage and a terrifying secret weapon set against the backdrop of the Cold War, is one of the great mysteries for Tintin-ologists.
Artcurial's comics expert Eric Leroy described the "Explorers on the Moon" as "a key moment in the history of comic book art... It has become mythic for many lovers and collectors of comic strips.
"It is one of the most important from Herge's postwar period, on the same level as 'Tintin in Tibet' and 'The Castafiore Emerald'," he added.