The 77-year-old actor will receive the Gregory Peck Award for Excellence in Cinema, reported Variety.
Stewart will be bestowed with the honour on October 5 at the Variety Night of the Stars Tribute at the Pendry Hotel in Downtown San Diego.
With a career spanning almost six decades, the legendary actor is known for roles such as Professor Charles Xavier in the "X-Men" series and Captain Jean-Luc Picard in the "Star Trek" film franchise.
Stewart was recently seen reprising his role as the powerful telepath in the X-Men epic "Logan".
The festival will run from October 4-8.
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