The sixth seeded Indo-American pair registered a 6-4 6-3 win over the Italian-Australian combination in one hour and 13 minutes in the second round of the prestigious clay court tournament.
There was little to separate the two teams as the winners scored a total of 59 points while Samantha and Francesca scored 47.
Both the teams had many a break chances but did not convert many. While Sania and Bethanie converted five of 12 chances, their rivals could cash in on just three off 11.