The pair clinched the Olympics berth on the weight of their doubles rankings in the top 10 on June 6. Currently, Sania is world No. 1 and Bopanna is ranked No. 15.
If they get past the Australian duo, the Indians could lock horns with either the Spanish team of David Ferrer and Carla Suarez Navarro or Romania's Florin Mergea and Monica Niculescu in the quarterfinals.
The top billing has been given to France's Caroline Garcia and Nicolas Mahut.
Sania will be playing in her third Olympics and has the doubles experience of 37 titles, which include six Grand Slam trophies.
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With medals at the Asian Games and the Commonwealth Games also in her kitty, Bopanna -- playing his second Olympics -- couldn't have asked for a better partner to launch a serious medal challenge in Rio.
Venus Williams has decided to play alongside Indian-American Rajeev Ram.