Sania and Martina Hingis of Switzerland, seeded number one in the women's doubles, lost to unseeded Czech Republic duo of Barbora Krejcikova and Katerina Siniakova 3-6 2-6 in a third round match.
Earlier in the day, the sixth seeded Indo-Romanian pair of Bopanna and Florin Mergea defeated Marcus Daniell and Brian Baker 6-2 6-7 (4) 6-1, while 16th seeds Paes and Marcin Matkowski stunned fourth seeded combination of Bruno Soares and Jamie Murray 7-6 (5) 7-6 (4).
In the women's doubles, Sania and Hingis, who were coming into the Grand Slam tournament after their Australian Open triumph earlier this year, were rusty against their unseeded Czech rivals and could not hold their serve five times in the match, including four in the second set.
Sania and Hingis gave away a break point to their opponents to lose the first set 3-6. They also began the second set on a poor note as they failed to hold their first two serves to trail 0-4.
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The Czech combo served for the match but Sania and Hingis were yet to throw in the rowel and broke their opponents' serve to make it 2-5.
But their was not be any further fightback from the Indo-Swiss duo as they yet again failed to hold onto their serve and lost the second set 2-6 to end the match in disappointment.
With today's loss, Sania and Hingis failed to realise their hopes of winning four Grand Slam titles on the trot. They had won Wimbledon and US Open doubles titles in 2015 and the Australian Open in 2016, the season's first Grand Slam in January.