If the Indo-Croatian pair manages to win tomorrow, it would be Sania's first Grand Slam title with Dodig and fourth major mixed doubles triumph overall.
The second-seeded combination will be clashing with the unseeded Abigail Spears of America and Colombian Juan Sebastian Cabal in the grand finale at Melbourne Park.
The 30-year-old has won three mixed doubles titles so far, the last being the 2014 US Open with Brazilian Bruno Soares.
With Dodig, she had an opportunity to win last year when she reached the French Open final but lost to compatriot Leander Paes and her then women's doubles partner Martina Hingis in the summit clash.
Sania is the lone Indian to have made all the way to the first Grand Slam final of the season as Paes, Rohan Bopanna, Purav Raja, Divij Sharan and juniors -- Zeel Desai and Siddhant Banthia -- all made early exits.
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