Sania and her Swiss partner Mirza lost 2-6 6-4 10-5 to Russian pair Elena Vesnina and Daria Kasatkina late last night.
The last time the Indo-Swiss pair, who have won three doubles Grand Slams in a row, had lost was way back in Cincinatti last August.
After surviving a gruelling three sets win over an unseeded Chinese pairing in the last round here, luck finally ran out for Sania and Hingis against the Russians despite dominanting the first set.
They started the year with wins in Brisbane and Sydney before completing a hat-trick of Grand Slam titles at the Australian Open. The duo had won the St Petersburg Ladies title earlier this month.