On the episode of the popular sitcom, Noah Galvin's openly gay character, Kenny, compared being bisexual to having "webbed toes" or "money problems", reported Entertainment Weekly.
Ramirez, who identifies as bisexual and played a bisexual character on "Grey's Anatomy", took to Twitter to express her displeasure over the episode.
"As someone who has worked (for) them (for) 10 years, (I) am truly disheartened and disappointed," she wrote, before adding, "Quite frankly, I will invest my brand where I am respected."
"Dear @ABCNetwork @TheRealONeals: own it, address it, clarify it, empower our #Queer #Bisexual youth and community w/accurate positive reflections," she quoted.