The 40-year-old actress, who has been on the show since the second season, posted a tweet on that sounded like a goodbye.
"That's a wrap for Doctor #CallieTorres #Season13 #GreysAnatomy #ThankYou all for an enriching & unforgettable #Rollercoaster ride!" she wrote.
A spokesperson for the long-running medical drama refused to comment about the tweet and the speculation about Ramirez's exit, reported Entertainment Weekly.
The actress' contract is up in June, it may be renewed.