"I received a call from the doctor on duty (at Jinnah Hospital) at 1 A.M. (1:30 IST) informing me that Sarabjit is no more," Mahmood Shaukat, the head of a medical board that was supervising 49-year-old Sarabjit's treatment, told PTI.
Another doctor, who was part of the team treating Sarabjit, said he died of cardiac arrest, adding that doctors made several unsuccessful attempts to resuscitate him.
Sarabjit sustained severe injuries when at least six prisoners attacked him in a barrack at Kot Lakhpat Jail on Friday, hitting him on the head with bricks.
In New Delhi, Prime Minister Manmohan Singh expressed sadness over Sarabjit's death, saying criminals responsible for the barbaric and murderous attack on the Indian national must be brought to justice.
Sarabjit was convicted of alleged involvement in a string of bomb attacks in Punjab province that killed 14 people in 1990 and spent about 22 years in Pakistani prisons.
His mercy petitions were rejected by the courts and former President Pervez Musharraf.
The previous Pakistan People's Party-led government put off Sarabjit's execution for an indefinite period in 2008.
Sarabjit's heart was beating "but without brain function" because of the extensive head injuries he sustained during the assault. He was completely unresponsive and unable to breathe without ventilator support.
Shaukat said authorities were yet to decide on conducting an autopsy on Sarabjit's body.
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