The 42-year-old star has joined James McAvoy, Anya Taylor-Joy, Bruce Willis and Samuel L Jackson in the film, according to The Hollywood Reporter.
Written by Shyamalan, "Glass" is a sequel to the 2000 thriller "Unbreakable", which followed Bruce Willis' character, David Dunn, who learns something extraordinary about himself after a devastating accident.
The film is expected to release on January 18, 2019.
Paulson is currently shooting for Steven Spielberg's "The Papers" alongside Tom Hanks and Meryl Streep.