After beating Romanian Constantin Lupulescu in the tiebreak games, Sasikiran took it easy in the first encounter of the two-game mini-match and gave little chance to Karjakin, ranked ninth in the world currently.
Grandmaster B Adhiban, however, could not make use of a good advantage and drew with Brazilian GM Alexander Fier after an opening tussle.
After a few surprises in the opener, most of the higher ranked players got off to a good start in the first game of second round in this USD 1.6 million knock-out event.
Julio Granda Zuniga of Peru, however, sprang a major surprise defeating Hungarian Peter Leko.
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Former national champion, Sasikiran surprised Karjakin by going for the King's Indian attack as white.
Karjakin spent more time in the opening but it was clear that the Russian was well-prepared and was only trying to remember the best moves. As the middle game approached, Karjakin got his counter play rolling on the queen side and Sasikiran had to play a bit cautiously to avoid giving any leeway.