The raids hit the Suq al-Hunod district of the Red Sea port, the official in the government of President Abedrabbo Mansour Hadi which is supported by the Saudi-led coalition told AFP.
The strikes were also reported by the rebel administration in the capital Sanaa, which reported civilian casualties without giving a specific toll.
The loyalist official said the residential neighbourhood was "probably hit in error."
Dr Khaled Suhail of Hodeida's Al-Thawra hospital said his facility alone received 12 dead and 30 wounded from the strikes.
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The Saudi-led coalition has been repeatedly criticised for the high civilian death toll from its 18-month-old bombing campaign in support of Hadi's government.
More than 6,600 people have been killed since the intervention began, the majority of them civilians, according to the United Nations.
The intervention has pushed the rebels out of much of the south, but they remain in control of nearly all of Yemen's Red Sea coast as well as the capital Sanaa and much of the central and northern highlands.
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