In the teaser, Hollywood fixer Eddie Mannix (Brolin) gets his toughest assignment yet when he's hired to track down a leading man (Clooney) who's been kidnapped by terrorists.
Eddie is forced to turn to Hollywood's acting royalty for help.
This movie reunites the Ethan Coen and Joel Coen with several members of their recurring ensemble - including Clooney, Brolin, Frances McDormand and Tilda Swinton.
"Hail, Caesar" hits US cinemas on February 5.