The porous structure possesses essential properties of natural bone marrow and can be used for the reproduction of stem cells at the laboratory.
This might facilitate the treatment of leukaemia in a few years, researchers said.
Scientists at Karlsruhe Institute of Technology (KIT), the Max Planck Institute for Intelligent Systems, Stuttgart, and Tubingen University developed the synthetic material that allows stem cells to multiply.
Blood cells, such as erythrocytes or immune cells, are continuously replaced by new ones supplied by hematopoietic stem cells located in a specialised niche of the bone marrow.
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However, not every leukaemia patient can be treated in this way, as the number of appropriate transplants is not sufficient.
This problem might be solved by the reproduction of hematopoietic stem cells. So far, this has been impossible, as these cells retain their stem cell properties in their natural environment only, ie in their niche of the bone marrow.
Researchers artificially reproduced major properties of natural bone marrow at the laboratory.
They added protein building blocks similar to those existing in the matrix of the bone marrow for the cells to anchor.
The scientists also inserted other cell types from the stem cell niche into the structure in order to ensure substance exchange.
Researchers introduced hematopoietic stem cells isolated from cord blood into this artificial bone marrow. Subsequent breeding of the cells took several days.
Analyses with various methods revealed that the cells really reproduce in the newly developed artificial bone marrow. Compared to standard cell cultivation methods, more stem cells retain their specific properties in the artificial bone marrow.