"The scientists found that a few mutations in a gene called CPA1, that makes an enzyme called carboxipeptidase-A1, are associated with the disease pancreatitis," CCMB Director Ch Mohan Rao said at a press conference.
"These mutations make the enzyme fold incorrectly; misfolded proteins lose activity. In addition, misfolded or unfolded proteins cause stress in the cells. Cells respond to this stress by producing different molecules, either to help the protein to fold or to degrade it. Such responses might cause damage to pancreas leading to pancreatitis," he said.
Chronic pancreatitis is more prevalent in south India and alcoholism and gall stones are the primary causes. However it is found to be occurring even otherwise, AIG Chairman D Nageshwar Reddy said.
The research has shown that the disease is caused by gene mutations, he said.