Following nine years of construction and testing, researchers at the Max Planck Institute for Plasma Physics in Greifswald injected a tiny amount of hydrogen into a doughnut-shaped device then zapped it with the equivalent of 6,000 microwave ovens.
The resulting super-hot gas, known as plasma, lasted just a fraction of a second before cooling down again, long enough for scientists to confidently declare the start of their experiment a success.
"Everything went well today," said Robert Wolf, a senior scientist involved with the project. "With a system as complex as this you have to make sure everything works perfectly and there's always a risk."
Scientists looked closely at the hiccups experienced during the start-up of the Large Hadron Collider in Switzerland more than five years ago to avoid similar mistakes, he said.
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The experiment in Greifswald is part of a world-wide effort to harness nuclear fusion, a process in which atoms join at extremely high temperatures and release large amounts of energy that's similar to what occurs inside the sun.
Advocates acknowledge that the technology is probably many decades away, but argue that once achieved it could replace fossil fuels and conventional nuclear fission reactors.
The device, known as a tokamak, was conceived by Soviet physicists in the 1950s and is considered fairly easy to build, but extremely difficult to operate.
The team in Greifswald, a port city on Germany's Baltic coast, is focused on a rival technology invented by the American physicist Lyman Spitzer in 1950.
Called a stellarator, the device has the same doughnut shape as a tokamak but uses a complicated system of magnetic coils instead of a current to achieve the same result.