The March for Science, coinciding with Earth Day, was set for more than 500 cities, anchored in Washington and to be joined by dozens of nonpartisan scientific professional societies in a turnout intended to combine political and how- to science demonstrations.
Marchers in Geneva carried signs that said, "Science, A Candle in the Dark" and "Science is the Answer." In Berlin, several thousand people participated in a march from the one of the city's universities to the Brandenburg Gate landmark.
In London, physicists, astronomers, biologists and celebrities gathered for a march past the city's most celebrated research institutions. Supporters carried signs showing images of a double helix and chemical symbols.
The protest was putting scientists, who generally shy away from advocacy and whose work depends on objective experimentation, into a more public position.
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Organisers portrayed the march as political but not partisan, promoting the understanding of science as well as defending it from various attacks, including proposed US government budget cuts under President Donald Trump, such as a 20 per cent slice of the National Institute of Health.
The sign that 9-year-old Sam Klimas held was red, handmade and personal: "Science saved my life." He had a form of brain cancer and has been healthy for eight years now. His mother, grandmother and brother travelled with him from Parkersburg, West Virginia.
"I have to do everything I can to oppose the policies of this administration," said his grandmother, Susan Sharp.
Scientists involved in the march said they were anxious about political and public rejection of established science such as climate change and the safety of vaccine immunisations.
"It is not just about Donald Trump, but there is also no question that marchers are saying 'when the shoe fits.