Singaporean Seah Chiang Nee, a former newspaper editor, died aged 76 in a local hospital on Saturday, his wife Patricia Wong told AFP. He was hospitalised in July.
Seah underwent heart transplant surgery on October 12, 1985 in Sydney, when doctors removed his organ in a five-and-a-half hour operation and replaced it with that of a 17-year-old boy who had just died.
"Based on his record he should be one of the longest-surviving in the world," said Kenneth Ng, a cardiologist at the Mount Elizabeth Novena Hospital in Singapore.
The world's longest surviving heart transplant patient was a Briton named John McCafferty, who died at age 73 last year, 33 years after the transplant, according to British media reports.
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In an interview with AFP in 2005, 20 years after the operation, Seah said he would have been content to live for four or five years after the transplant.
He said he had never imagined he would be able to welcome the new millennium.
"Twenty years is a long, long time and I'm already very grateful," he said then.