In an excerpt of the interview broadcast today, Penn said his goal in meeting with Guzman was to shine a light on America's role in the international drug trade.
"We are the consumer. Whether you agree with Sean Penn or not, there is a complicity there," Penn said told journalist Charlie Rose, in an interview scheduled to air in full Sunday on the CBS program "60 Minutes."
"If you are in the moral right, or on the far left, just as many of your children are doing these drugs," the actor said.
Penn added: "I have a regret that the entire discussion about this article ignores its purpose, which was to try to contribute to this discussion about the policy in the war on drugs."
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His interview was published last Saturday in Rolling Stone, triggering a barrage of criticism, including condemnation of Penn himself.
Among other things, the ire has centered on Penn's letting Guzman review the piece before it ran; seeming to glorify -- or at least go easy on -- a man blamed for thousands of deaths in Mexico's drug-related violence and contributing to drug addiction in America.
Penn challenged the Mexican government's assertion that the interview -- held in an undisclosed location in Mexico -- helped the authorities track down Guzman, who was captured the day before the article was published.
"There is this myth about the visit that we made, my colleagues and I with El Chapo, that it was -- as the attorney general of Mexico is quoted -- 'essential' to his capture," the actor said.
"We had met with him many weeks earlier...On October 2, in a place nowhere near where he was captured.