Sehwag blasted 73 off only 39 deliveries and added 135 runs with Mahela Jayawardene (55 off 42 balls) as Mumbai Indian bowlers were sent on a leatherhunt.
Kevin Pietersen smashed an unbeaten 50 with six fours and three sixes to provide finishing touches to the hosts innings.
It was contrasting styles from two of the modern day greats. While Sehwag made a mockery of the opposition bowlers with his power-hitting, Jayawardene was more intent on caressing the ball to the boundary.
Not to forget Pietersen who scored a 50 off only 26 balls and added 41 runs in only 2.4 overs with Ross Taylor (15) as Daredevils crossed 200-run mark.
The onslaught started in the third over when Jayawardene decided to launch into Malinga hitting him for three boundaries. A lofted shot over mid-wicket, followed by one past backward square followed by square cut.
In the next over, Jayawardene hit a copybook cover drive and Daredevils were off the blocks. Sehwag who kept quiet after his first boundary then slashed RP Singh over point and lofted him for a straight six